{"id":3835,"date":"2007-06-08T10:26:03","date_gmt":"2007-06-08T03:26:03","guid":{"rendered":"http:\/\/swallow-nest.com\/article\/2007\/06\/08\/occurrence-of-a-nonsulfated-chondroitin-proteoglycan-in-the-dried-saliva-of-collocalia-swiftlets-edible-birds-nest\/"},"modified":"2007-06-08T10:26:03","modified_gmt":"2007-06-08T03:26:03","slug":"occurrence-of-a-nonsulfated-chondroitin-proteoglycan-in-the-dried-saliva-of-collocalia-swiftlets-edible-birds-nest","status":"publish","type":"post","link":"https:\/\/indonesia-product.com\/news\/occurrence-of-a-nonsulfated-chondroitin-proteoglycan-in-the-dried-saliva-of-collocalia-swiftlets-edible-birds-nest\/","title":{"rendered":"Occurrence of a nonsulfated chondroitin proteoglycan in the dried saliva of Collocalia swiftlets (edible bird's-nest)"},"content":{"rendered":"


\ningentaconnect.com
\nAuthors: Nakagawa, Hiroki; Hama, Yoichiro; Sumi, Toshihisa; Li, Su-Chen; Maskos, Karol; Kalayanamitra, Kittiwan; Mizumoto, Shuji; Sugahara, Kazuyuki; Li, Yu-Teh<\/p>\n

Source: Glycobiology, Volume 17, Number 2, 1 February 2007 , pp. 157-164(8)<\/p>\n

Publisher: Oxford University Press<\/p>\n

Abstract:<\/p>\n

Despite their wide occurrence, proteoglycans (PGs) have never been isolated from the saliva of higher animals. We found that the Collocalia glycoproteins isolated from edible birds’-nests (the dried forms of regurgitated saliva of male Collocalia swiftlets) were rich in a PG containing nonsulfated chondroitin glycosaminoglycans (GAGs).
\n<\/p>\n

We have devised a method to isolate a PG from the water extract of the white nest built by Aerodramus fuciphagus (white nest swiftlets) with a yield of 2-mg PG per gram nest. This PG contained 83% of carbohydrates, of which 79% were GalNAc and GlcUA (D-glucuronic acid) in an equimolar ratio. By using chondroitin AC lyase, the structure of GAGs in this PG was established to be chondroitin ( \u2192 4GlcUA\u03b21 \u2192 3GalNAc\u03b21 \u2192 )n<\/inf> chains. The average molecular mass of the chondroitin chain was estimated to be 49 kDa by gel filtration. We have isolated a linkage region hexasaccharide, \u0394HexUA\u03b11 \u2192 3GalNAc\u03b21 \u2192 4GlcUA\u03b21 \u2192 3Gal\u03b21 \u2192 3Gal\u03b21 \u2192 4Xyl, from this PG by chondroitinase ABC digestion to show that the GAGs in this PG are also linked to the core protein through the common tetrasaccharide linker, GlcUA\u03b21 \u2192 3Gal\u03b21 \u2192 3Gal\u03b21 \u2192 4Xyl, found in various PGs. As water was not effective in extracting uronic acid-containing glycoconjugates from the black nest built by black nest swiftlets (A. maximus), we used 4 M guanidium chloride and anion-exchange chromatography in the presence of urea to extract and isolate about 30 mg of a chondroitin PG preparation from 10 g of the desialylated black nest. As the biological significance of chondroitin is still not well understood, bird’s nest should become a convenient source for preparing this unique GAG to study its biological functions.
\nDocument Type: Research article<\/p>\n","protected":false},"excerpt":{"rendered":"

ingentaconnect.com Authors: Nakagawa, Hiroki; Hama, Yoichiro; Sumi, Toshihisa; Li, Su-Chen; Maskos, Karol; Kalayanamitra, Kittiwan; Mizumoto, Shuji; Sugahara, Kazuyuki; Li, Yu-Teh Source: Glycobiology, Volume 17, Number 2, 1 February 2007 , pp. 157-164(8) Publisher: Oxford University Press Abstract: Despite their wide occurrence, proteoglycans (PGs) have never been isolated from the saliva of higher animals. We found […]<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[413],"tags":[],"yoast_head":"\nOccurrence of a nonsulfated chondroitin proteoglycan in the dried saliva of Collocalia swiftlets (edible bird's-nest) - Directory of wholesale, manufacturers, distributors, importer and exporter in Indonesia<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/indonesia-product.com\/news\/occurrence-of-a-nonsulfated-chondroitin-proteoglycan-in-the-dried-saliva-of-collocalia-swiftlets-edible-birds-nest\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Occurrence of a nonsulfated chondroitin proteoglycan in the dried saliva of Collocalia swiftlets (edible bird's-nest) - Directory of wholesale, manufacturers, distributors, importer and exporter in Indonesia\" \/>\n<meta property=\"og:description\" content=\"ingentaconnect.com Authors: Nakagawa, Hiroki; Hama, Yoichiro; Sumi, Toshihisa; Li, Su-Chen; Maskos, Karol; Kalayanamitra, Kittiwan; Mizumoto, Shuji; Sugahara, Kazuyuki; Li, Yu-Teh Source: Glycobiology, Volume 17, Number 2, 1 February 2007 , pp. 157-164(8) Publisher: Oxford University Press Abstract: Despite their wide occurrence, proteoglycans (PGs) have never been isolated from the saliva of higher animals. 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